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Home / HP / Solid State Drives / HP P22278-S21

HP P22278-S21 3.84TB PCIe x4 NVMe U.3 2.5" SFF Read Intensive DS SSD

Part Number: P22278-S21     Brand: HP
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P22278-S21 HP Image

P22278-S21 Price

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$3,804.00 $3,845.95
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Condition
Quantity

HP P22278-S21 Specs

▲
Brand
HP
Capacity
3.84TB
Workload
Read Intensive (RI)
Encryption
Digitally Signed (DS)
Form Factor
2.5" SFF
Drive Interface
U.3
Data Transfer Lanes
x4
Data Transfer Protocol
NVMe
HPE Server Generations
Gen 10+/Gen 10

This HP Solid State Drive P22278-S21 is compatible with these HP Servers

▲
ProLiant DL365
Proliant DL360
Proliant DL560
Proliant DL580

HP P22278-S21 Description

▼

The HP P22278-S21 3.84TB PCIe x4 NVMe U.3 2.5" SFF Read Intensive DS SSD is a high-performance solid-state drive designed to meet the demanding storage needs of enterprise environments. Ideal for applications requiring fast read speeds and reliable data access, this SSD is compatible with a wide range of HPE ProLiant server models including ProLiant DX, DL, ML, SL, BL, XL, and CL series. Whether you are upgrading your server storage or building a new system, this drive supports HPE Gen 10 and Gen 10+ server generations, ensuring seamless integration and optimal performance.

Key specifications of this SSD highlight its robust capabilities and advanced features. With a large 3.84TB capacity, it is well-suited for read-intensive workloads, making it perfect for data analytics, virtualization, and database applications. The drive uses the NVMe protocol over a U.3 interface with PCIe x4 lanes, delivering ultra-fast data transfer speeds and low latency. Its 2.5" Small Form Factor (SFF) design allows for easy installation in compatible server bays. Additionally, the drive includes digitally signed encryption to enhance data security and integrity.

  • Brand: HP
  • Capacity: 3.84TB
  • Workload: Read Intensive (RI)
  • Encryption: Digitally Signed (DS)
  • Form Factor: 2.5" Small Form Factor (SFF)
  • Drive Interface: U.3
  • Data Transfer Lanes: PCIe x4
  • Data Transfer Protocol: NVMe
  • HPE Server Generations: Gen 10+ / Gen 10

For maintenance or replacement, the following spare part numbers are associated with this SSD:

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ⓘ We found 12 subs for the HP P22278-S21
100% Match
HP P20614-001 3.84TB PCIe NVMe U.3 2.5" SFF Read Intensive SC DS SSD
✓ Capacity: 3.84TB
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
98% Match
HP P19817-B21 3.84TB PCIe 4.0 NVMe U.3 2.5" SFF Read Intensive SC SSD
✓ Capacity: 3.84TB
+ Interface: PCIe 3.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
98% Match
HP P20615-001 3.84TB PCIe 4.0 NVMe U.3 2.5" SFF Read Intensive SC DS SSD
✓ Capacity: 3.84TB
+ Interface: PCIe 3.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
98% Match
HP P20803-001 3.84TB PCIe 4.0 x4 NVMe U.3 2.5" SFF Read Intensive SC DS SSD
✓ Capacity: 3.84TB
+ Interface: PCIe 4.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
98% Match
HP P47846-B21 3.84TB PCIe NVMe U.3 2.5" SFF Read Intensive TLC DS SSD
✓ Capacity: 3.84TB
+ Interface: IDE
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
98% Match
HP P44576-B21 3.84TB PCIe NVMe U.3 2.5" SFF Read Intensive SC DS SSD
✓ Capacity: 3.84TB
+ Interface: PCIe 4.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
98% Match
HP P20133-B21 3.84TB IDE NVMe U.3 2.5" SFF Read Intensive TLC DS SSD
✓ Capacity: 3.84TB
+ Interface: PCIe 3.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
96% Match
HP P22278-B21 3.84TB PCIe x4 NVMe U.3 2.5" SFF Read Intensive SC DS SSD
✓ Capacity: 3.84TB
+ Interface: PCIe
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
+ Hot-Swappable: Yes
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
96% Match
HP P44580-B21 3.84TB PCIe NVMe U.3 2.5" SFF Read Intensive DS SSD
✓ Capacity: 3.84TB
+ Interface: PCIe 4.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
+ Data Transfer Rate: 12Gb/s
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
94% Match
HP P48225-001 3.84TB PCIe 4.0 x4 NVMe U.3 2.5" SFF Read Intensive TLC DS SSD
✓ Capacity: 3.84TB
+ Interface: IDE
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
+ NAND Flash Memory Type: Triple-Level Cell (TLC)
+ Hot-Swappable: Yes
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
94% Match
HP P40566-B21 3.84TB PCIe 4.0 x4 NVMe U.3 2.5" SFF Read Intensive DS SSD
+ Spindle Speed: 10K
✓ Capacity: 3.84TB
+ Interface: PCIe 4.0
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
+ Data Transfer Rate: 12Gb/s
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3
92% Match
HP P16503-B21 3.84TB PCIe x4 NVMe U.3 2.5" SFF Read Intensive SC DS SSD
+ Spindle Speed: 10K
✓ Capacity: 3.84TB
+ Interface: SAS
✓ Form Factor: 2.5" SFF
✓ Brand: HP
✓ Workload: Read Intensive (RI)
+ NAND Flash Memory Type: Triple-Level Cell (TLC)
+ Data Transfer Rate: 24Gb/s
✓ Encryption: Digitally Signed (DS)
✓ Data Transfer Lanes: x4
✓ Data Transfer Protocol: NVMe
✓ Drive Interface: U.3

Customer Reviews

4.8
★★★★★
289 reviews
94% recommend
5
(253)
4
(21)
3
(9)
2
(2)
1
(4)
G
Gary B.
2025-06-12
✓ Verified Buyer
★★★★★
The sales guy at Boost Hardware was super knowledgeable. He helped me find the right part for my older Proliant server.
E
Even P.
2025-04-09
✓ Verified Buyer
★★★★★
We purchased the wrong part by mistake. Boost hardware made it easy to return and quickly issued me a refund.
M
Matthew S.
2025-04-08
✓ Verified Buyer
★★★★★
Good purchasing experience.
A
Aaron P.
2025-04-04
✓ Verified Buyer
★★★★★
The refurbished drives we ordered were in perfect condition.
M
Mitch F.
2025-04-04
✓ Verified Buyer
★★★★★
BoostHardware always has what I need at reasonable prices.
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David P.
2025-03-28
✓ Verified Buyer
★★★★★
Delivered on time.
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Louis J.
2025-03-26
✓ Verified Buyer
★★★★★
Found the hard drives I needed. The ordering process was smooth and fast. Got the drives next day.
D
Darryl P.
2025-03-25
✓ Verified Buyer
★★★★★
Excellent personal service, thanks Scott!
L
Lindsay M.
2025-03-21
✓ Verified Buyer
★★★★★
Good price on the drives we needed.

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